Chapter 470 The Biggest Difficulty in the Development of Smallpox Vaccine

With the hospital in place and the manpower in place, Gretel rolled up his sleeves and got to work.

The front yard, also known as the outpatient department, is still sluggish and empty. There are only about ten patients who come in every day. The five healers sitting in the clinic are so busy that one Buddha was born and two Buddhas ascended to heaven. I wish everyone had a cat:

This is not to say that you can use petting to relieve irritability. The main thing is to throw a ball of wool to the cat, and then pick it up and tidy it up when it messes up. You can also find something to do for yourself...

In the backyard, that is, the research department, work is proceeding in an orderly manner. The things that have troubled Leon Carlos for half a year are almost no problems for Grete:

"You try freezing, drying, and freeze-drying. The three methods are applied staggered. The freezing temperature ranges from -20 degrees to -10 degrees, and from 2 degrees to 10 degrees. Each degree is used as a grid."

His expression didn't change, and he reported a long list of things without thinking. Well, how should vaccines be stored? I don’t know, I haven’t studied it, it’s not in the textbooks. This is not the scope of applied medicine. Making vaccines is the job of bioengineering next door...

Fortunately, during the epidemic before traveling through time, Gretel had heard about it, and it seemed that there were several storage temperatures. Gretel relied on this fragment of knowledge to talk and talk, and he seemed to be quite able to bluff people.

Well, he is the big boss, so he can just give you direction. When doing experiments or something, of course someone will run the errands to do it!

Leon Carlos brushed his records and could hardly keep up with his speed. As for how to achieve Gretel's request, it can be done by adjusting the magic circle, but it will burn up the budget...

"If you want to dry, don't use heating. You can use natural drying, dehumidifier, or use magic to drain the moisture." Gretel's instructions continued:

"I remember... there is a magic called [Thirst Touch]?"

"That's right, first-level necromancy magic." Carlos became more energetic. This magic, through touch, can cause living creatures to quickly and massively lose water and fall into a dehydrated state. Although there are quite a few restrictions and the price/performance ratio is relatively low, it seems to be just right for vaccine dehydration?

"But, I don't know this magic..."

He was a little ashamed. Although he is a necromancy magician and has advanced to become a formal mage, he is just an academy student - in other words, without the guidance of a direct mentor, his grandma does not love his uncle.

Some of the most common magics in the necromancy system, such as fighting the undead (yes, the introductory magic of the necromantic system is to fight the undead, which can be said to be a model of "I kill myself"), touch of fatigue, touch of cold, ray of weakness, You can still learn it in college. [Touch of Thirst] This kind of niche magic...

"Oh, I'll give you the information later."

Grete responded nonchalantly. The Horn of Thunder has rich reserves. Archmage Carlisle threw him countless spell models before, including [Touch of Thirst].

A mere first-level magic is taught to the magician in the mage tower. I don’t think the school will care...

As for freeze-drying, they had done it before when making penicillin and had ready-made experience. Now they just copy it.

Carlos took the order and left. Gretel sat alone at the desk, holding her chin in her hands and thinking:

How to verify the effectiveness of the vaccine made?

If it were replaced by a cholera vaccine or a plague vaccine, it would be very simple, and a large number of animals could be used for experiments. But the smallpox vaccine is not effective. Smallpox is notorious for only infecting humans. Rats, rabbits, dogs, pigs, nothing can be used...

Grete began to claw at his scalp. After grabbing it for a while, the oak stick rolled up with the [Endless Ink Pen] jumped out of his pocket and started writing:

Technical route 1: Use cows as verification objects. 20 freezing temperatures, 10 vaccines per group, storage time of 2 days, 3 days, 4 days, 15 days, 30 days. A total of... 1,000 cows are needed? !

Are there so many cattle around Nevis? How much budget does it take to get so many cows?

Technical route 2: Use primates as verification objects. The same grouping method requires... 1,000 monkeys?

The oak staff trembled. Press down on the [Endless Ink Pen] to draw a deep and long trace on this technical route.

Technical route 3: Use humans as verification objects...

Dr. Jenner did the same thing back then, vaccinating people directly with cowpox vaccine, and then, a few months later, vaccinated with variola. A successful vaccination with variola indicates that cowpox does not produce protection; a failed vaccination with variola indicates that the vaccine is successful.

The advantage of this route is that the city of Nevis lacks people for everything. If you want to find 1,000 people as experimental subjects, you are absolutely not afraid of not being able to find them; the disadvantage is...

Gretel sadly discovered that he still had some social fear. It is easier for him to sit in the hospital and treat 1,000 patients, but it is easier for him to go to the street and grab 1,000 normal people and convince them to be experimental subjects for cowpox vaccination...

Just thinking about it, I thought, forget it, I might as well kill him.

As a doctor, a doctor in a public tertiary hospital, and an emergency physician in a tertiary hospital, I have never worried about too many patients, not too few. How to attract patients, he has no experience!

Wow, how did Dr. Jenner find so many test subjects back then?

Gretel struggled to recall, and sadly discovered that Dr. Jenner seemed to have only treated a dozen people back then. So why do I need 1,000 people? Is there something wrong with my experimental design, or are my requirements too high?

Hey, I was too hasty before. All the apprentices and nurses have been vaccinated, and there are no experimental subjects left...

Grete held his head, groaned, and hit his head on the desk. A clang startled Annevia who pushed the door in and said:

"Sir, what's wrong with you?"

"Who should I inoculate with cowpox..." Gretel rested his forehead on the edge of the table and groaned. Anivea came forward holding the tray, took a look at the manuscripts on the table, and laughed:

"A thousand people? Sir, it's easy to get a thousand people. In which month has our treatment center at the port not been able to get a thousand patients?"

Gretel stood up.

yes!

Make the treatment center famous!

Let the people around you feel that this is a reliable place!

Grete grabbed the pen from the root of the oak staff and began to write. Once you open your mind, the ways to find people become rich and colorful:

1. Build the reputation of the treatment center and attract more patients. This is the right path, and if you run it well, it has unlimited potential;

2. Go to the surrounding areas to send doctors to the countryside, and vaccinate people on the way. It must be said that he was wearing a linen robe, holding an oak staff, and riding an Appa. He was still very impressive and easy to believe. Find 20 experimental subjects in one village and visit 50 villages, and the task will be completed;

3. Talk to the city hall and ask for some prisoners for experiments. The city hall may not necessarily buy it. It may first need to communicate with the public health department, or use the teacher's banner;

4. Ask the surrounding lords for help. They will lead the people and provide vaccines themselves...

Although the verification of vaccinia vaccine requires a thousand people, these people do not have to come at the same time: considering that later vaccination with variola requires isolation and observation, in fact, only 20 to 40 people are needed for each batch. If there are more cases, the hospital's treatment capacity will not be able to cope with it.

Calculating it this way, the pressure is actually not great.

"Annivea! Come on, let's go to the front for a consultation!"

However, the addition of Gretel did not make the situation better at first. For the poor people who come to their homes, experienced therapists will give some medicine for mild cases and treatment for severe cases, and the problem will usually be solved within ten minutes. Only Grete, ten minutes is not enough for him to check:

"Sir, what is your name?"

"age?"

"What's wrong with you?"

"Stand up and let me take a look... Hey, take off your coat and all those metal accessories!"

"Okay, lie down, lift up your clothes, and let me take a look..."

Inspection, questioning, auscultation, palpation. X-ray, B-ultrasound, electrocardiogram. The time to collect the patient's condition was three times longer than the treatment time. In this way, the final answer is probably still:

"Sir, please take this packet of medicine..."

"Sir, let me give you a treatment..."

Just, very waste of time.

And they even steal patients!

The priests who worked with him looked sideways. Mr. Gretel Nordmark, although you are our employer, can you stop taking our jobs?

We also need to accumulate treatment experience when we advance!

Because the amount of treatment here is too small, we have divided the work, and each person only comes for half a day!

Mark Saren, the third-level priest of the Temple of the God of War, rolled up his sleeves, put the treatment table on his shoulders, and silently moved it to the gate.

Hannah, the second-level priest of the Order of the God of Nature, immediately followed. She didn't even need to ask for help, she urged the plant to roll up the two table legs, then raised one edge of the table herself, and moved the treatment table to the other side of the door.

Gretel: "..."

As for that? As for doing this to me? Didn’t I just spend more time checking? I didn’t leave you to work overtime!

snort! If you have the ability, keep grabbing it! If you have the ability, don’t encounter difficult and complicated diseases that cannot be dealt with!

Gretel made circles in her mind angrily. However, difficult and complicated symptoms soon appeared - Mark came over and called him with a face full of embarrassment:

"Master Nordmark, can you come and take a look? I have treated this patient more than once and he keeps relapsing!"

Gretel got up and went out. As soon as the visitor saw him, he put on a smile, his chubby face spread out to both sides, and his eyes narrowed until there was only a slit left:

"Pastor Nordmark!—Do you remember me?"

...To be honest, his face looks familiar, but I can’t remember his name. Grete swept from top to bottom, from bottom to top, pausing at his obviously enlarged finger joints, and suddenly realized:

"Oh... you are the one... I treated gout for you! How are you doing recently? Do your fingers and toes still hurt? Do you still eat sea fish and wine?"

"I don't dare to eat. I don't dare to eat." The businessman nodded and bowed, with a smile on his face. He helped the white-haired old man walk into Grete's consulting room and sat down across from his desk:

"My father coughed up blood again... He went to see more than one priest, but he was cured at the same time, but relapsed two months later... Pastor Nordmark, can you take a look?"

****

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I checked the papers related to vaccine storage and transportation temperature, basically all of them are about veterinary vaccines...despair...

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