Chapter 440 Come on and Hurt Each Other

"Now we are under a lot of pressure!" The strength of pharmaceutical companies is here. They have built thick barriers, so that consumers have no choice at all. You can either pay a lot of money to buy my medicine, or stay at home. It's okay to die, if the supply to the country is reduced, and the pharmaceutical factory can't produce enough medicine in a short period of time, it will be troublesome.

"It's okay. Nova will not make up its mind so quickly. Now they are just intimidating. We still have time." Shen Long comforted, but in fact it was not the case. He had already prepared for this and thought it over Coping strategies, but this method is not suitable for Professor Ma Lin and the others to know.

"Then it's best, let's hurry up and start trial production! As long as the produced medicine can meet the needs of patients, it won't be a problem for Nova to reduce the supply." Professor Ma Lin and Director Qiao were a little relieved .

After they left, Shen Long turned on his computer and got ready to work. Nova had many problems. The governments of other countries were dissatisfied with them, and the pharmaceutical giants also had conflicts. The contradictions in order to attract the attention of Nova Company, so that they can not take care of their own affairs for the time being.

This is the same as using other local governments to help him relieve pressure before, but the chosen target is different. Shen Long carefully recalled the information he collected, and decided to put the target on Avastin, which is a drug developed by Roche Pharmaceuticals. Anticancer drug, chemical name "bevacizumab", is a drug that hinders angiogenesis. It blocks the blood supply to tumors by inhibiting the effect of vascular endothelial growth factor, inhibits the spread of tumors in the body, and enhances the effect of chemotherapy.

The efficacy of the drug is very significant, and it was very popular in the market once it was launched. Its annual sales are similar to those of Glenin, and it is an out-and-out blockbuster drug (the industry's name for drugs with annual sales of more than one billion US dollars).

At first glance, this drug does not seem to have anything to do with Nova, but some doctors accidentally found that Avastin has a very good therapeutic effect on patients with blindness caused by macular degeneration. This use gradually spread, and many doctors began prescribing the drug off-label to patients with macular degeneration.

Off-label medication refers to a drug that is used for indications other than those approved by regulatory authorities such as the FDA (Food and Drug Administration), and is not included in the instructions; for example, metronidazole was originally used to treat trichomonas vaginitis, but Your gums hurt and the doctor also prescribes you metronidazole. You are stupid when you see it. You go to the doctor and tell the doctor that I am a man. The doctor says it’s okay. It doesn't hurt anymore, this medicine is really amazing!

The proliferation of Avastin's off-label drugs is very detrimental to Nova, because they also have their own products in the field of macular degeneration treatment. These doctors' off-label drugs undoubtedly have an extremely detrimental effect on the sales of Nova's drugs Since this drug is already very good, why spend more money on Nova's drug?

Now Nova has not paid much attention to this situation, so Shen Long wrote an email,

The situation was analyzed and then anonymously sent to Nova executives.

After they know about this, they will definitely sue the doctors who take off-label drugs, and Roche will definitely take corresponding measures for their own interests. It will be interesting for these two pharmaceutical giants to fight, compared with this incident Come to think of it, what are the trivial matters in China?

After all, China's economy is not developed now, Nova's interests in China are far from being compared with Avastin's influence on them, and Roche is not so easy to deal with, they have rich litigation experience, if this lawsuit is fought That would be a long time, and it would also be an opportunity to expose the greed of pharmaceutical companies.

After a period of litigation between Roche and Novavax, they will understand that it is not a good choice for pharmaceutical giants like them to start a war with each other, so they will definitely compromise and seek a more effective way of cooperation, such as establishing a A community of interests like the vitamin C price alliance monopolizes the macular degeneration drug market and raises prices.

It stands to reason that Roche can redo the clinical trials of Avastin, and if it is confirmed that it is effective for macular degeneration, this indication can be added to the label, but this drug is developed for cancer, because of the dosage etc. For various reasons, it is much cheaper for ophthalmology patients to use this drug than Nova's.

In this case, Roche is not happy, because providing drugs that are cheaper than the market violates their principles. They have always sold them as expensive as they can, so they might as well unite with Nova to monopolize this market.

They also did this in history. Not only was Roche unwilling to carry out clinical research on Avastin for the treatment of macular degeneration, but it launched legal measures to prevent doctors from using Avastin to treat patients with eye diseases.

This kind of behavior caused an uproar in the academic circles, and the governments of many countries were also extremely dissatisfied with it. The Italian government issued a fine of 1.6 billion US dollars to them, and the French government launched an investigation on them.

Shen Long's email seemed to help them, allowing Nova to discover the threat of Avastin in advance, but in fact it dug a hole for Nova and brought them even more trouble.

However, only these are not enough. After all, Nova Company is a giant, and they have enough energy to start two wars at the same time, so Shen Long started to write new emails.

This email is about Nova’s use of bribes to pass the FDA review. Bribery by pharmaceutical companies is not uncommon in the world. There are a lot of explosions in later generations. Some people even wrote articles and published them in the world like "Science" It couldn't be easier to find some black materials from Nova in the top journals.

In the email, Shen Long exposed the list of people who accepted bribes during the approval process of Nova’s new drugs. These people received bribes ranging from hundreds of thousands to millions of dollars from Nova to facilitate the approval of Nova.

In addition to direct bribery, there are also indirect bribery. Many officials in charge of reviewing new drugs worked for several years before jumping to a pharmaceutical company and getting a high-paying position. If you look at the list of companies they will go to in the future, people will easily find the chain of interests that exists in it.

There is also Nova's sponsorship of politicians from various countries. They spend hundreds of millions of dollars every year to let these people settle all kinds of troubles for them. Once exposed, it will be an out-and-out scandal.

Come on, hurt each other, let's see who can't stand it first!