Chapter 591 Meeting with AstraZeneca
Remember [New] in one second! Kyoto University First Affiliated Hospital.
Emergency Internal Medicine Department.
In the ward, the alarm sound of the monitor and the shouting of the medical staff were mixed together.
"Doctor Fan, the patient is ill again!"
The patient on the bed rolled his eyes upwards, began to twitch violently, and spit out white foam from the corners of his mouth.
Fan Jian had already rushed to the bedside and shouted: "One diazepam, intravenous push!"
The emergency department nurses had a high level of rescue quality and immediately prepared diazepam injection.
Just as the nurse was about to give the patient the medicine.
Lu Chen discovered something very strange, "Wait a minute!"
He pointed to the ECG monitor next to the patient's bed.
On the ECG monitor, the ECG was a straight line!
This is so scary.
A straight line on the ECG means that the patient may have stopped the ECG activity!
In other words, the patient's heart may have stopped. .
To be more straightforward, the patient may have died.
Fan Jian looked in the direction Lu Chen pointed.
Sure enough, the electrocardiogram was a straight line!
Lu Chen felt uneasy and was ready to rush over and perform CPR.
Fan Jian quickly felt the patient's carotid artery pulse, but he couldn't feel it.
But after a few seconds, he could feel the pulse.
At this time, the nurse shouted again, the heartbeat is back!
Fan Jian's back was covered with cold sweat, fortunately it was a false alarm.
Then, the patient's convulsions also stopped, less than 10 seconds before and after.
Fan Jian shook his head helplessly: "A patient with epilepsy, the cause of the disease has not been figured out yet, this is good, the heartbeat stopped directly. It's really too aggrieved!"
But at this moment, Lu Chen suddenly froze, he seemed to have known why the patient had an epileptic seizure.
Lu Chen walked forward, quickly checked the patient's pupils on both sides, re-measured the blood pressure, and confirmed that the patient's vital signs had stabilized.
At this time, the patient had woken up.
"Lu Chen, what's wrong?" Fan Jian stared at Lu Chen in surprise, did he find something again?
"Can you call up the patient's ECG monitor record?" Lu Chen asked.
"Of course." Fan Jian nodded, turned around and told the nurse to call up the ECG monitor record.
The nurse quickly called up the record.
Lu Chen looked through the patient's ECG monitor record and matched the time. The patient's heart rate was fine before the attack, more than 80 beats per minute, but when the convulsion started, the heart stopped beating, and there was a long rr interval that lasted for 7 seconds.
"That's the problem!" Lu Chen said in a deep voice.
Fan Jian looked at Lu Chen in confusion, not quite understanding what Lu Chen meant, "What's wrong?"
"The patient should have cardiac arrest first, followed by convulsions." Lu Chen said slowly. "It seems that the convulsions are caused by cardiology diseases, not epilepsy as we have always thought."
Fan Jian was stunned, "Lu Chen, you mean, this is Asperger's syndrome?"
Lu Chen nodded slightly, "Yes, it is Asperger's syndrome!"
The so-called Asperger's syndrome refers to a disease in which the heart suddenly pumps insufficient blood or does not pump blood at all due to some reason, causing cerebral ischemia and hypoxia, resulting in syncope and convulsions.
The heart beats too slowly, or the heart does not beat at all, or beats too fast, which may lead to insufficient blood pumping and syncope and convulsions.
The final diagnosis is only a thin layer of window paper away from reality.
Lu Chen broke through this layer of paper, and the doctors present were all suddenly enlightened.
Originally, Fan Jian and his team also considered the possibility of heart disease at the beginning, so they also arranged for dynamic electrocardiograms, cardiac color ultrasound, etc., but no abnormalities were found.
"Why are there no problems with cardiac ultrasound and electrocardiogram?" Fan Jian said.
Lu Chen smiled, "Because during the examination, the patient did not have convulsions, so naturally there was no cardiac arrest. The ECG at this time would definitely not provide any evidence."
Fan Jian nodded, "That makes sense, but why didn't the patient have cardiac arrest at the beginning?"
Lu Chen patiently explained, "The patient's initial attack was only convulsions on one side of his limbs, and he was still conscious. Considering that the cerebral ischemia was not serious at the time."
"Later, the arrhythmia worsened, and the arrest time may have been prolonged, which led to impaired consciousness and a full-blown epileptic seizure. The patient never felt chest tightness, chest pain, palpitations, or other discomfort before the epileptic seizure."
Just now, the patient suddenly convulsed, and the attack occurred directly under the eyes of the attending physician and the ECG monitor.
So, the real culprit was finally caught!
Just when Lu Chen finished speaking, he noticed that a prompt popped up on the system.
"Congratulations, I received a thank you from Fan Jian +1!"
"Congratulations, the system upgrade completion rate has increased!"
...
"Lu Chen, it's all thanks to you."
Fan Jian patted Lu Chen's shoulder. He didn't expect Lu Chen to help him solve the problem for the second time.
Lu Chen smiled. He also accidentally discovered that the patient's electrocardiogram was a straight line.
"Do you have a bed? Take this patient to your department?" Fan Jian said again.
Now that epilepsy has been ruled out, he will not go to the neurology department, but will need to be hospitalized in the cardiology department.
"There is a bed available, so you can go." Lu Chen nodded, "But Brother Fan, you have to talk to the patient first. He may need to complete the electrophysiological examination and may need a pacemaker. If he doesn't have surgery, there may be no need to go."
"Okay, as long as there is a bed, I will communicate with the patient." Fan Jian grinned. It would be better to transfer such a high-risk patient out as soon as possible.
…
Return to the doctor's office in Heart 1.
Lu Chen told the nurse that he was going to receive a patient from the emergency department.
Although this patient did not have medical insurance, his employer reimbursed him in full!
"Brother, I have a question about the patient just now." Su Rui whispered.
"Ask." Lu Chen smiled. He liked this little junior sister, not because she was beautiful, but because... she could earn thank you points!
Su Rui blinked and asked, "How come this kind of patient doesn't have any symptoms before getting sick? Such as chest tightness, chest pain, palpitations..."
Lu Chen explained with a smile, "Not every patient with arrhythmia will feel uncomfortable. Some people don't have any heart discomfort and fall to the ground directly. Later, it was found that they had sick sinus syndrome. Heart disease The beating is irregular, the brain is ischemic, and it will turn black in a few seconds and then fall down.”
"Wouldn't that be dangerous?"
"Yes." Lu Chen nodded, "So after the specific cause is found out, this patient may need a pacemaker."
Su Rui nodded as she listened. In her eyes, senior brother Lu Chen was so awesome. He knew everything he asked. He was like a treasure chest!
…
Kyoto University First Affiliated Hospital.
General Surgery Ward 1, doctor's office.
Since arriving at Kyoto University, Wang Zihao has felt tremendous pressure!
He never thought that one day he would be able to stand in the top medical school in China.
All around are academic masters and academic gods...
Although he was usually careless and didn't care much about other people's opinions, he was still hit hard in this fiercely competitive environment.
In the entire department, his clinical knowledge and skills may be the worst.
However, a recently published sci paper allowed him to turn the situation around!
As a professional master, it is not easy to be able to complete a SCI paper alone.
Even at Kyoto University, where top academics gather, only a small number of people can accomplish this achievement.
After publishing this sci paper, Wang Zihao instantly felt confident!
Usually in the department, he walks straight.
After returning to the dormitory after get off work, Wang Zihao was about to go find Lu Chen, but he didn't expect his sister Wang Ruoxi to call.
"Zihao, are you with Lu Chen now?"
I thought Wang Ruoxi cared about his younger brother, but she opened her mouth to ask about Lu Chen.
"Yes, sister, what's the matter?"
Wang Zihao knew that his sister had paid "special attention" to Lu Chen for some time.
However, after Lu Chen didn't respond, Wang Ruoxi suspended the offensive.
Is the old love rekindled this time?
Could it be that Lu Chen was going to be his brother-in-law again?
Wang Zihao was very confused. Lu Chen was good, but it was so strange to change from brother to brother-in-law!
Just listen to Wang Ruoxi continue: "Recently, Lu Chen published a paper on dapagliflozin, right?"
"Yeah." Wang Zihao responded. He knew that his sister happened to be AstraZeneca's Jinghua regional manager.
Wang Ruoxi said in a deep voice: "Zihao, there is something I need to tell you the truth about."
"Sister, what you said is right. I am your brother and I will definitely not lie to you!" Wang Zihao said in surprise.
Listening to the serious tone of the elder sister, isn't it about emotions?
Wang Ruoxi paused and said slowly: "Then tell me, did Lu Chen complete this paper by himself, or did his tutor help?"
When Wang Zihao heard this, he blurted out: "It must have been completed by Lu Chen alone! Professor Li Yao gave some advice at most, and most of the content was completed by Lu Chen himself."
"Really?" Wang Ruoxi still didn't believe it.
This is not a two or three point sci paper!
But one of the top journals in the cardiovascular field!
The department directors of many provincial tertiary hospitals have not reached this level...
"Really! I promise!" Wang Zihao said immediately.
On the other end of the phone, Wang Ruoxi was a little silent. He knew that Lu Chen was unusual, but he still underestimated him.
This time, the superiors actually noticed him.
"Okay, I understand. I'll come to Kyoto to find you tomorrow."
After Wang Ruoxi finished speaking, she hung up the phone.
Listening to the busy signal from the other end of the phone, Wang Zihao curled his lips and said, "That's nice, you're looking for me? You're probably looking for Lu Chen..."
…
As for Lu Chen, his mentor Li Yao also contacted him.
"Lu Chen, people from AstraZeneca may be in contact with you recently." Li Yao vaccinated Lu Chen in advance. "They should be talking to you about the Dagli Pure Country Natural Project."
When Lu Chen saw the news, he was a little confused.
"Teacher, why did AstraZeneca come to me?"
"I don't know the details, but they are very interested in your paper." Li Yao replied, "You completed this paper independently, so I asked their people to find you directly."
Although Li Yao has a corresponding author, she is really in Lu Chen's favor.
"Okay, thank you teacher, I understand." Lu Chen was quite confused.
Why did AstraZeneca come to him? Isn't there a competitive relationship between them?
Is AstraZeneca here to "recruit"?
At the same time, Lu Chen also learned from Wang Zihao that Wang Ruoxi would come to Kyoto.
It seems that what Professor Li Yao said was right. AstraZeneca is coming!
…
The next day.
Lu Chen was blocked by Wang Ruoxi downstairs of the dormitory just after get off work.
"Lu Chen, long time no see."
Wang Ruoxi was wearing a black business suit, but it still couldn't hide her good figure. She had short hair that reached her shoulders, and she looked very capable and charming.
"Sister Ruoxi, why did you come all the way to Kyoto?" Lu Chen greeted her with a smile.
Wang Ruoxi also provided a lot of support for his National Natural Science Foundation project on dapagliflozin. For example, all experimental drugs were sold at a discount price.
This saved Lu Chen a lot of project funds!
"Brother Lu Chen, I came here to find you, and it's a big deal." Wang Ruoxi is not much older than Lu Chen, but she has been in the workplace for many years, and her tone is more mature and sophisticated than Lu Chen.
"Do you have time? Let's talk somewhere else."
"Okay."
With a beautiful woman by his side, Lu Chen is willing to do it.
Facing patients in the hospital every day, it is sometimes quite boring.
They found a coffee shop near the hospital, found a booth, and started chatting.
Lu Chen is not used to the coffee here, and he always adds a lot of sugar.
"Brother Lu Chen, taste it slowly, and the bitterness will be rewarded with sweetness." Wang Ruoxi gently sipped the unsweetened coffee.
"Forget it, I'll add sugar." In his opinion, life is already very difficult in many cases, so the external feelings should be as sweet as possible.
"Sister Ruoxi, I heard from my mentor that you came here this time for the matter of dapagliflozin?" Lu Chen said straight to the point.
"It's okay, why can't I come to see you?" Wang Ruoxi put down the coffee cup and said softly.
Lu Chen secretly glanced at Wang Ruoxi's delicate face, then retracted his gaze and coughed lightly, "Of course."
"I won't tease you." Wang Ruoxi retracted her smile and said seriously: "I heard from Zihao that the 12-point SCI paper you recently published was basically completed by you independently?"
Lu Chen shook his head slightly.
"No?" Wang Ruoxi was stunned.
Lu Chen said slowly: "First of all, this SCI paper is not 12 points, but 11.98 points; secondly, I can only say that most of it was completed independently by me, and the statistical methods were helped by a professor from Kyoto University."
Lu Chen told the truth, and anyone with a discerning eye could see that this statistical method was really not something that ordinary people could do!
"I thought it was something else." Wang Ruoxi smiled. She mainly wanted to ask if Lu Chen was just a figurehead.
Generally speaking, if a professional master can have one or two low-scoring SCI papers, it would be quite excellent.
Once the SCI impact factor exceeds 5 points, then you have to consider whether this is not a "scholar clique"!
The second generation of students nowadays is even better than the second generation of officials and the second generation of rich people.
They started studying genes in elementary school. How embarrassed are many masters and doctors?
"Lu Chen, actually, I came to you this time to represent the AstraZeneca China Division." Wang Ruoxi said slowly.
Lu Chen smiled, "Sister Ruoxi, just tell me what you want to talk to me about?"
Wang Ruoxi paused, "I want you to cooperate."
"Cooperation?" Lu Chen was puzzled, "Aren't you AstraZeneca also doing this experiment?"
Thinking of this, he was suddenly stunned. Could it be that AstraZeneca wants to turn their experiment into a "branch center" of AstraZeneca?
If so, Lu Chen's independent National Natural Science Project will become a subsidiary of AstraZeneca and become a Chinese branch center for clinical research.
Although there is no need to compete with AstraZeneca, it has lost the original meaning of the experiment, which is no different from choosing to "lie flat".
"Lu Chen, don't get me wrong." Wang Ruoxi seemed to have seen through what Lu Chen was thinking. "The one currently conducting the same experiment as you is not AstraZeneca headquarters, but a European branch."
"Branch?" Lu Chen frowned. "What's the problem?"
"There are many problems." Wang Ruoxi smiled. "If it is a clinical study led by AstraZeneca headquarters, then we won't talk much. We are definitely in a competitive relationship. Now the one competing with you in scientific research is just a European branch. Our Chinese branch and the European branch are actually in a competitive relationship."
"Aren't they all the same company? Why is it so complicated?" Lu Chen asked in confusion.
Wang Ruoxi shook her head. "AstraZeneca is a multinational giant company. The more such a company is, the more complicated the relationships are. People in the branch all want to be promoted to the headquarters. Therefore, there is a certain degree of competition between each branch. This mainly depends on which district has improved its performance the most, or who produces more influential scientific research."
Hearing this, Lu Chen understood a little.
"Oh, so you want to cooperate with me on the dapagliflozin project, and want to use it to compete with the European branch?"
Wang Ruoxi smiled and nodded: "Yes! The headquarters supports this kind of scientific research competition, because no matter which side wins, the AstraZeneca headquarters will benefit in the end!"
Lu Chen curled his lips, these Europeans and Americans, they have a good plan!
No matter which branch wins, it will benefit the AstraZeneca headquarters in the end, so the headquarters acquiesced to this kind of competition.
"In fact, we didn't intend to compete with the European branch on this project. The progress in Europe is very fast, and we can't catch up at all." Wang Ruoxi said again, "But because of your sudden rise, our Huaxia branch noticed you, and then we have the intention to compete with the European branch again."
Lu Chen frowned upon hearing this.
At present, if nothing unexpected happens, the experimental progress of AstraZeneca's European branch will definitely be faster than theirs!
In this way, the cooperation request from the Huaxia branch is an opportunity.
But AstraZeneca is a foreign company after all, a blood-sucking capitalist. If they can't see clear benefits, they will definitely not act easily.
"How do you want to cooperate?" Lu Chen looked up at Wang Ruoxi.