Chapter 321: Research that Changes Clinical Guidelines?

"Lu Chen, there is a male patient who needs a urinary catheter. Please come and help. He is in bed 10."

Gong Nannan walked into the doctor's office and smiled at Lu Chen.

"Okay, coming soon."

Lu Chen was writing down the course of his illness. When he heard nurse Gong Nannan's words, he stood up and walked out of the office.

Since Lu Chen came to the emergency department, many male patients had to leave all matters of urinary catheterization to him.

Therefore, catheterization became one of the skills for which Lu Chen's proficiency reached 100% the fastest.

Bed No. 10 is a young man in his twenties.

"Don't be nervous, you'll be fine soon." Lu Chen came to the bedside of bed No. 10.

The young man looked green and a little embarrassed, and whispered: "Oh, please be gentle."

"Don't worry, take off your pants first." Lu Chen placed the catheter bag on the bedside console.

"Ah? This..." The young man's face turned red.

"What are you afraid of? It's just a big man." Lu Chen said sternly, "It will be over soon."

"Oh." The young man took off his pants hesitantly.

About a minute later.

"Okay." Lu Chen smiled and said to the young man in front of him, "There's nothing uncomfortable."

The young man nodded: "Thank you."

Lu Chen wrapped the remaining medical waste and threw it into the yellow medical waste barrel.

"Congratulations, I received a +1 thank you from Ma Ping!"

A urinary catheter was inserted and I got some gratitude points.

Lu Chen left the emergency ward with satisfaction.

…

"Hey, Lu Chen, I heard that our opening time for this year has been advanced."

As soon as he returned to the doctor's office, Cheng Peng came over.

"When will it be advanced?" Lu Chen was stunned.

He has been busy doing clinical research data recently, and he really didn't notice these things.

The topic proposal involves the direction of the topic and determines the research direction for the entire three-year postgraduate program.

"Probably after New Year's Day." Cheng Peng thought for a while.

"After New Year's Day?" Lu Chen frowned.

The national electrocardiogram competition takes place almost during New Year's Day.

In other words, after he finishes the competition and returns to school, he will almost have to start the project.

"It's not because something happened to a certain celebrity. He got a Ph.D., and even CNKI doesn't know what it is." Cheng Peng curled his lips, "Now the Ministry of Education has stricter review of papers. In the past, the duplication rate was no more than 20%. In our current class, the score is less than 10%, which is so weird! So in order to allow us to prepare the paper earlier, the school has moved up the time for opening the paper. "

Lu Chen also heard about this celebrity.

However, the quality of Huaxia's papers is indeed poor now. Many of them are just one article, or they can be graduated after translating foreign texts.

"Time is running out." Lu Chen thought to himself.

The usual question opening time is the start of the second semester, but this year it has been moved forward to the first semester.

Lu Chen has some ideas for his clinical topic, but he still needs preliminary data support.

He is currently doing research on this early data.

If even the early data is meaningless, then there is no need for him to continue.

The most important thing now is to get the early data out quickly before New Year's Day.

…

Eight zones in the heart.

Office of the Director.

Lu Chen, Ke Yue and Jiang Qingyan stood in front of the desk.

Li Yao looked down at the proposal reports of the three people.

Sometimes the corners of his mouth are raised, and sometimes his brows are wrinkled.

A long while.

Li Yao said slowly: "Well, Jiang Qingyan has a good idea. The research direction on the toxic effects of anti-tumor drugs on cardiovascular disease is very interesting. Research in this field abroad is very mature, but it is still in its infancy in China. ”

"But, Ke Yue, your proposal report..." Li Yao raised her head and glanced at Ke Yue, "How should I put it, studying the relationship between platelet aggregation and cardiovascular disease does not seem to be a problem, but have you ever read it? Other people’s research documents?”

Ke Yue lowered her head, "Look, I've seen it..."

"Then you should also know that there are already many mature research and development results in your research field. If you try it again, although there are no fatal problems in the entire research topic, it will be difficult to make something more innovative. In a word, it is like tasteless , It’s tasteless to eat, it’s a pity to throw it away.”

"Yes." Ke Yue's voice was thin and weak, "Teacher, I will look for the literature when I go back."

Li Yao nodded and said nothing more.

Only Lu Chen's proposal report was left, and Li Yao did not express any opinions.

It was a little quiet in the office.

Li Yao's right index finger tapped lightly on the table, making a small and regular sound.

After a long while, Li Yao raised her head and looked at Lu Chen.

"Regarding the study of dapagliflozin in preventing early heart failure in patients with acute myocardial infarction, was this research topic your own idea?"

Ke Yue and Jiang Qingyan looked at Lu Chen standing aside.

Is there any problem with this topic?

Lu Chen nodded slightly.

In fact, with the help of the system, he applied the clinical scientific research skill card and combined it with the current popular research field of cardiovascular medicine.

Finally, I finally came up with this research topic.

"Very good, very good!" Li Yao said twice in a row, "Dapagliflozin is a popular drug at present. Major laboratories around the world are researching it. The research and development direction you chose should be blank at home and abroad! If you can do it well and publish a high-scoring SCI, there will be no problem."

"Even if the sample size of the study is large, a large sample, multi-center clinical study is conducted, and the final research and development conclusion can even change the clinical treatment guidelines!"

Change clinical guidelines?

Everyone present, including Lu Chen, all showed astonishment.

Lu Chen originally just wanted to publish an SCI paper, but he didn't expect Li Yao to give such a high evaluation.

Ke Yue and Jiang Qingyan looked at Lu Chen in disbelief.

No one could have imagined that a research proposal made by a graduate student could change clinical guidelines!

Li Yao continued, "Don't be so surprised. You should know that Dapagliflozin has just been included in the list of conventional drugs for the treatment of heart failure. The medical field has recognized its status. However, there is no clinical research on acute myocardial infarction, so it has not been included."

"But..."

Li Yao changed the subject and stared at Lu Chen closely: "Everyone knows that clinical research is not difficult because of the method! It requires a lot of manpower, material resources and financial resources! The sample size you wrote in the opening report is only 50 people. With this sample size, at most one low-scoring SCI paper can be published. If you want to change the clinical guidelines, then the sample size must be at least tens of thousands of people! Generally, this kind of research on changing clinical guidelines is led by the leading hospitals in the country and the major tertiary hospitals. The sample size is large, and only such research results are applicable to clinical practice."

Lu Chen nodded. He understood what Li Yao meant.

In clinical research, good ideas are important, but they require a lot of financial and material resources.

In prospective research, a sample of only 50 people is definitely not enough, and it can even be said to be very little!

But the sample size of 50 people requires tens of thousands of dollars, or even more.

This is also the limit that Lu Chen can bear at present.

It is not realistic for Lu Chen to spend more money on clinical research!

"Let's do this." Li Yao continued, "Lu Chen, you should first do a sample of 50 people. If the preliminary experimental research is meaningful, then consider whether there is a possibility of further progress."

"Okay, teacher." Lu Chen smiled.

"In fact, the sample of 50 people costs a lot of money." Li Yao said in a deep voice, "I will give you a partial subsidy in the name of the laboratory. Secondly, when you collect data, I will let the medical staff of the eight cardiac areas cooperate with you."

The so-called prospective research requires patients to return to the hospital for review in time, which involves examination fees, round-trip travel expenses, etc.

"Thank you, teacher!" Lu Chen looked happy.

The biggest obstacle for him now is not the funds, but the cooperation of the medical staff in the department if he wants to do a good job in clinical experiments, otherwise it is difficult to collect first-hand data.

Now with Li Yao's sword, Lu Chen's future clinical research should be much easier.

"By the way, you two too." Li Yao said to Ke Yue and Jiang Qingyan, "I will ask the nurses in the department to cooperate with you."

"Thank you, teacher." Ke Yue and Jiang Qingyan said in unison.

When they walked out of the director's office, Lu Chen and the other two showed happy expressions on their faces.

As a mentor, Li Yao was already quite responsible for being able to do this.

Many graduate mentors basically let their students fend for themselves.

Some mentors even impose some unreliable research on their students.

...

Looking at the backs of the three people leaving the office, Li Yao was very pleased.

The quality of students in this class is too high.

The clinical research topics of Lu Chen and Jiang Qingyan are very innovative, and they should be able to produce good results.

Ke Yu's topic is a little worse, but he is qualified for graduation.

Li Yao did not give such convenient conditions to the students of the previous two classes.

This can be seen from Senior Sister Wang Shasha.

"I hope the three of them will not let me down."

Li Yao looked at the three opening reports in front of him with a smile on his face.

…

Leaving the doctor's office, Lu Chen and the other two walked on the path of the hospital.

"Lu Chen, you are really amazing. The teacher said that your topic can even change the clinical guidelines!" Ke Yue couldn't help but give Lu Chen a thumbs up.

"That requires a large sample size. I only have 50 samples now, and it is enough to publish an SCI paper." Lu Chen smiled.

This is not his modesty, it is determined by the sample size.

"Oh, it's already very impressive!" Ke Yue smiled.

At the same time, she was also very happy.

It seems that helping Lu Chen record data is a very correct choice!

If Lu Chen publishes an SCI paper with her name, it will be a big profit.

"Jiang Qingyan's topic is not bad." Lu Chen smiled, "Ke Yue, you have to revise your proposal report."

Jiang Qingyan smiled.

Ke Yue pouted, "Oh, I know, it seems that I have to stay up late again..."

The three chatted all the way and separated in front of the dormitory for regular training.

…

Back in the dormitory, everyone was discussing the topic.

"The preliminary data of my project is almost done." Wang Zihao patted Lu Chen on the shoulder, "I still have to thank Lu Chen for this! Without you, I wouldn't be so fast."

"Hey, I don't even have any ideas, and I'm about to start the project. It's really difficult!"

Another roommate Xing Yu frowned.

"Brother Yu, go ask your boss! Doesn't he have any projects?" Wang Zihao asked in confusion, "Just let you do a sub-project, it should be enough for you to graduate, right?"

"Hey, I asked." Xing Yu smiled bitterly, "My boss asked me to think about it myself, and then let him change it after I think about it. As for his project, I don't think he can handle it himself. He is looking for an outsourced laboratory to do it. If you want him to give me a sub-project, forget it."

"Uh... It's really difficult for you to meet an unreliable boss." Wang Zihao shook his head slightly, then looked at Lu Chen on the side, "Lu Chen, have you finished your clinical project?"

"The opening report has been written, but the preliminary data has not been completed yet." Lu Chen shook his head.

"Then hurry up." Wang Zihao said, "I remember you are going to Bingcheng to participate in the electrocardiogram competition, right? When you come back from Bingcheng, we will almost have to start the project."

"Yes." Lu Chen nodded, "I asked two classmates to help, and they should be able to complete the preliminary data."

"That's good." Wang Zihao said.

The dormitory chatted for a while.

Wang Zihao suddenly received a WeChat message. After reading it, he said, "Lu Chen, my sister wants to treat you to dinner again."

Lu Chen was processing clinical research data, and was stunned when he heard this.

"Didn't she eat it some time ago? Why eat it again?"

"Last time it was a thank-you banquet, and this time she is going to come to the hospital for a follow-up visit." Wang Zihao said, "So I want to make an appointment with you in advance to learn some information from you."

"This... is not necessary." Lu Chen said, "Your sister is coming for a follow-up visit, just let her go to the cardiology clinic. I can't prescribe medicine or do any tests here."

"I told her all this, but she still wants to come to you." Wang Zihao said, "Lu Chen, just think of it as a free meal, it's only a morning anyway. So that my sister won't bother me again."

Lu Chen thought for a while and said, "When?"

"Tomorrow is the weekend, UU Reading www.uukanshu.net just let him know, 11:30 noon, at the Shangri-La Hotel."

"Shangri-La... isn't cheap?" Lu Chen said with a smile.

"Don't worry, my sister is a rich woman." Wang Zihao smiled, "You can't make her poor even if you eat a few more meals."

At this time, Xing Yu whispered beside him: "Zihao, I also want to have a meal, I don't want to work hard..."

"Go away, go away." Wang Zihao laughed and scolded, then looked at Lu Chen, "What do you think, do you want to go?"

Lu Chen nodded: "Since you said so, I will definitely go. But can we change the place? The restaurant in front of our hospital, the taste is very good, the price is also affordable, I still have to process data tomorrow afternoon. Besides, going to a high-end Western restaurant like Shangri-La is too restrained, and the appetite is not much better."

"This should be no problem, I will contact my sister." Wang Zihao smiled.

...