Three Hundred and One Come, Come, Come, Listen to Me

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Where will the future of human medicine go. Zhang Fan had never considered this issue before. What Zhang Fan considered at the beginning was how medical care could provide him with food and clothing, so that he could buy a house and marry a wife.

Later, when all these were in place, Zhang Fan would occasionally think about it, and then when the surgical operation level reached the system's second-level requirements, which was already the peak level in reality, Zhang Fan really began to think about it.

Maybe it's because Zhang Fan is just an ordinary person, but this is more representative of the mentality of the majority of medical professionals. Just like every ordinary doctor in every hospital, if you ask where the medical industry will go in the future, he must wait for the mortgage to be paid off! Doctors are also ordinary people, but society has given him more moral requirements.

As for the future of medical treatment, in fact, Zhang Fan's answer now is that the future of medical treatment will definitely go to replacement surgery. Many doctors say that the future will be minimally invasive and interventional, but Zhang Fan definitely does not agree with that. Minimally invasive and interventional surgery at most means reducing the size of the current surgery. Combined with the apoptosis factors in human cells, the future of medical treatment is definitely replacement surgery.

As far as the human engine heart is concerned, with the increase of interventional surgery, there are more and more disadvantages, especially under the brutal promotion of commercialization, the disadvantages are hidden. The 10-year blockage rate is already an important problem that interventional surgery has to face. subject. Of course, the benefits are also obvious.

In the system, Zhang Fan quickly went through the heart surgery operation. The operating room was ready, and the operation was just waiting for Zhang Fan to open his eyes.

"Zhang Yuan!" Director Lin glanced at Zhang Fan worriedly, he thought Zhang Fan was too tired

"It's okay!" Zhang Fan shook his head.

And the four students have already started to mutter in their hearts, "Closing your eyes before the operation is some kind of special trick?"

Extracardiac surgery is quite strenuous compared to general orthopedics.

For orthopedic surgery and general surgery, it doesn’t matter if you cut a little more, such as rubbing a swollen appendix! But it is different outside the heart. To a certain extent, the surgery outside the heart requires more refinement than the surgery outside the brain. The surgery outside the heart is not to mention an extra knife. Sometimes an extra needle may kill a person.

Zhang Fan, Director Lin, and the original director and deputy director of cardiac surgery, the four of them worked on the operating table for a whole morning. Cardiac surgery not only requires good skills, but also good equipment and materials.

"The material of the valve needs to be changed!" Zhang Fan said inexplicably when the valve was replaced.

Director Lin was stunned for a moment, and the first thought in his mind was: This material is made of sunshine! The equipment representative is a man! Then I thought: Is this not advanced?

Valve, what is this thing, it's actually a window.

The heart is like a suite with four housing prices, the gate is the aortic valve, and the mitral and tricuspid valves are the windows.

Blood is air, that's probably what it means.

If you talk about it in detail, it will be more troublesome. The initial perfusion volume and fluid movement are really troublesome things.

Some people have said that if you want to understand the liver, you need to be good at chemistry and biochemistry, and if you want to understand the heart, you need to be good at physics and electrophysiology.

Replacing windows, let alone the heart, is a rather troublesome thing for ordinary people, and the valves are currently divided into three types, one is the mechanical valve, and the material is often titanium, because this thing is the only one that does not affect the autonomic nerves. Metal material, the second type is the heart valve of pigs and cattle, and the third type is the interventional umbrella type.

What Zhang Fan uses today is a mechanical valve. How can I say this thing? It has obvious advantages and disadvantages. It needs to take anticoagulant drugs for life. Even if it is taken for life, it is easy to form blood clots near the valve.

After the operation was completed, Zhang Fan said hello and left in a hurry. Director Lin felt that Zhang Fan was very strange today.

As soon as Zhang Fan came out of the operating room, he started calling, "Ms. Zeng, I, Zhang Fan, do you have time now? If so, please come to the administration building."

Ms. Zeng was in a meeting, and one of them was so busy that she wanted to become three, but on Zhang Fan's phone call, she was leisurely drinking afternoon tea.

Zhang Fan immediately called Zhao Yanfang again. Old Zhao was very honest and was busy nursing the baby. If there was nothing serious, we can talk about it tomorrow.

In the administrative building, Wang Hong led Zhang Fan's four students with her chest up and stood at the door waiting for the meeting crowd.

After a while, Ms. Zeng arrived first, and was seen to come

Early in the morning, they changed into a special set of clothes at this time. Under Mao Ni's coat was a black lace skirt, and the black silk insteps were exposed from the small bow shoes at the neck.

When Zhao Yanfang came, everyone was there.

"The current heart valves have their own advantages and disadvantages. I have an idea, can we invent a product that combines all the advantages in clinical practice and has fewer disadvantages?"

As soon as he said this, Old Zhao began to frown.

"The biggest disadvantage of all valves in clinical practice is that they will generate relatively large turbulent flow stress (which can cause fatal or semi-fatal damage to red blood cells and platelets) and larger pressure gradient and reverse flow volume than normal heart valves. If only In response to anticoagulation or increasing the use time, if the cost pressure is not high, I think it can still be taken seriously.”

It sounds like Lao Zhao supports Zhang Fan, but when he thinks about it carefully, he is against it. People say that there is a level, which means that you can’t change the biggest disadvantage, so don’t do it, it’s a waste of money, you might as well give it to me if you have this money!

Ms. Zeng sat there quietly with a smile on her face, as if she had come to attend a lady's afternoon tea, without a single trace of superfluous expression on her face.

She knew that she had better be a little transparent at this time, if she said something inappropriate, it would not be worthwhile for Zhang Fan to give him a hammer.

In human terms, turbulent flow means that the blood in the blood vessels is swirling. There are red blood cells in the blood, which carry oxygen. This thing is like the face of a big-faced cat, which is disc-shaped and very delicate.

After the turbulence occurs, these things rub against each other and collide with each other, and the big face plate will break. Once broken, it will lose the function of transporting oxygen.

Many diseases can cause turbulent flow, such as the heart's disobedient beating, bouncing and chasing becomes bouncing and chasing. At this time, there will be countless turbulent flows inside the heart, causing blood to fail to flow out of the heart, and the effect of the defibrillator is, A big slap woke up the heart, and it started to bounce.

In the past, Zhang Fan never thought about researching and developing any kind of equipment. First, he didn’t have the time, and second, he didn’t have the technology.

It’s different now. In order to avoid letting the parent company interfere too much in their business, or to avoid gossip, several big companies jointly established a new company, and it was registered in China, and the hospital also had shares. company, which is tantamount to being your own company.

And Zhang Fan needs such a new company now. They come up with their own ideas, they come up with technology, and finally they work together to make products. Otherwise, if you cooperate with these old capitalist companies, you will not know how you died.

Is there such a company in China? Yes, but it can be seen from the valve market that Huaguo is still not good at this aspect. For example, biofilms are commonly used in valves in Europe and the United States, while mechanical membranes are commonly used in China. From this point, Zhang Fan can only borrow chickens to lay eggs.

"Hehe, I think so too. If you don't have money, don't think about it. Ms. Zeng is an expert in this area."

Zhang Fan said something to Lao Zhao with a smile, and then looked at Ms. Zeng. With an embarrassed smile on Ms. Zeng's face, it's okay to say no, and it's okay to say yes. Really, she now feels that Zhang Fan is getting harder and harder to serve.

Old Zhao pouted, Zhang Fan turned to Wang Hong and said, "Prepare for a confidentiality agreement."

Wang Hong is now a generalist, from uploading and issuing to business classification, and now even knows a little bit about legal affairs.

"What on earth do you want to do? It's so exciting." Old Wang asked curiously, but Zhang Fan didn't speak yet.

Ms. Zeng spoke first: "Currently, Medtronic and St. Jude's mechanical valve products occupy more than 80% of the global artificial valve market, but now Abbott and Edwards Biofilm have surpassed Medtronic. The biggest advantage of biofilms is that they don’t need to take anticoagulant drugs for a long time, but biological attenuation is their flaw.”

Zhang Fan nodded. Zhang Fan didn't know who had the most market share.

But what Zhang Fan understood was the length of these two instruments.

After signing the agreement, it was done in a short while. After Wang Hong went out with the legal affairs officer of the hospital.

Zhang Fan started, "I have an idea now, using pure pyrolytic carbon combined with biology to manufacture the next generation of heart valves."

biological valve

What does the biodegradation of the membrane mean? To put it simply, put your finger in your mouth for a little longer, will the finger turn white and the skin fall off? This is actually what it means.

The heart valve needs to be tightly seamed. If there is a slight gap, it is just like a middle-aged man peeing. It is no longer a straight line, and it starts to diverge like a flower wine. It is reasonable to pee with one hand if you are not careful. .

Zhang Fanyi said that Old Zhao's face was wrinkled like a rag, "I'm not very familiar with this area."

Zhang Fan felt happy, Nima finally has something you don't understand, but he didn't show it on his face.

"Today is a briefing, I mean you need to build a team first, from materials to mechanics and biology, you need some people, and they must be top-notch talents.

After the team is formed, I will come up with the paper. "

Ms. Zeng said with a puzzled look: "Pure pyrolytic carbon was popular for a while, but then everyone left the biological item, and this one was shelved."

"Yes, my idea is not just pure pyrolytic carbon, but the coupling of pyrolytic carbon and biological valve!"

Zhang Fan is reluctant to say more, because in the system, the valve devices are all pyrolytic carbon and bio-coupled valves. So Zhang Fan is not afraid of going the wrong way.