Chapter 955 I Agree

"Let me first talk about the current development of medicine and biology at home and abroad. Let me explain clearly in a few words." Yang Rui thought for a while, and said: "In short, since the 1970s, the development of new drugs in the world During the golden age, a series of original drugs and imitated innovative drugs were launched successively, including the first β-adrenergic blocker propranolol, histamine H2 receptor blockers cimetidine and ranitidine , are the first cases, many patients have been saved, and the profit is also very high. This has brought about the development of new drug research theory for nearly 20 years, and the development of various technical platforms and methods is also very fast. For now, China has not kept up with the times at all.”

Yang Rui glanced at the three people and saw that they were indeed listening, so he continued: "As far as we are concerned, our backwardness in new drug research cannot be changed in a short period of time. The reason is also very simple. Our country has no money. At present, the investment in new drug research and development is about 400 million US dollars per drug, but this figure will soar rapidly. As far as I predict, by the end of the 1980s, the capital cost of a new drug will rise to 1 billion to 15 billion US dollars. billion dollars, and the R&D cycle increases to 10 to 12 years..."

Yang Rui made a prediction indifferently, but he didn't know that this kind of prediction seldom appeared when he was giving lectures to big bosses—it's okay if you guessed right, but if you guessed wrong, you're doomed.

Yang Rui was not afraid of this, and he talked about many problems in drug research and development without any scruples, and spread out about the domestic biopharmaceutical industry.

He is so familiar with these contents that he can say them accurately and in detail without thinking too much.

The three listeners also listened very seriously. The pharmaceutical industry is currently one of the few high-tech industries in China that can earn foreign exchange. Although compared with the international level, the high-tech industry is very poor, but it is still a very important industry. It is naturally necessary to take two hours to understand.

Tang Gong even took out his notebook to make a brief record, and when Yang Rui paused, he asked, "Yang Rui, I heard that you have made a new drug, which has been sold to foreigners and is of high value?"

Yang Rui said without hesitation: "Yes, I signed a milestone contract, and the total value of the contract exceeds ten million dollars."

The three seniors looked at each other, and none of them asked where the money had gone.

But Mr. Tang asked with great interest: "If such a drug is developed in China, is it possible?"

Yang Rui thought for a while and said, "Although I don't want to say it, I think it's unlikely."

"kindness?"

"The development of new drugs is a probabilistic problem. As far as the current situation is concerned, the cost budget for developing a new compound is 50 million U.S. dollars. Of course, 5 million U.S. dollars may also be possible, but 5 million U.S. dollars may be nothing. arrive,

Therefore, in order not to lose everything, a budget of 50 million US dollars needs to be prepared. "Yang Rui paused for a moment, and then said: "The domestic budget cost may be a little higher. After all, there is no equipment or anything, so we have to buy new ones." What I'm talking about is just making new compounds, just like what I did before. If it is a complete drug development, it will take longer, less efficient, and less realistic. "

"So, domestic pharmaceutical companies can no longer produce original drugs?" Tang Gong looked a little regretful, probably the type of person who can't see the loss of profits.

After thinking for a while, Yang Rui said, "I am in favor of making generic drugs first, and then original drugs, but the goal of making generic drugs should be to make original drugs, not just copying all the way."

Yang Rui paused as he spoke, and said, "Intellectual property rights and patent protection are the foundation of new drug research and development, otherwise, no company would spend 1 billion US dollars to make wedding dresses for people."

When he said this, he naturally thought of the history of generic drug development in India. India in later generations has become a purely generic drug country, and their national policy even requires pharmaceutical companies to force authorization. Of course, in the current India, this system and regulations are not perfect.

Therefore, Yang Rui once again said in the form of prediction: "There is a fundamental difference between the development of the generic drug industry with the original drug as the goal and the generic drug industry with the generic drug as the goal. Japan is currently taking the former path. Seeing the dawn, the Indian government is currently taking the latter path, and it is expected to achieve considerable results..."

Immediately afterwards, Yang Rui spoke out the policies that India would implement, saying: "I estimate that India's generic drug industry can grow bigger. However, generic drugs will be limited to original drugs after all. Policy changes , and even changes in the international form will affect their industries, which is not very suitable for China to learn from.”

What the three bigwigs want to hear is of course national content, and Yang Rui's answer is also extremely attractive.

The pharmaceutical industry is a trillion-dollar industry in the world, and it is one of the largest industries. Moreover, its consumption of resources is extremely small, and it belongs to the category of extremely high added value. Countries with a little idea can't wait depending on it.

"So, if we want to develop original medicines in China, do you think it is feasible?" Mr. Tang asked about the specific steps, which is already at the level of policy consultation.

Yang Rui thought for a moment, and said: "In general, I think four or five five-year plans should be able to see the results. However, the cost of drug research and development is so high, it should take the enterprise as the main body and fully consider the benefits. Otherwise, no matter how rich the country's finances are, it will not be able to support such a long and huge investment. For now, I think the implementation of GMP is a good strategy."

"GMP is Good Manufacturing Practice?"

"Yes, GMP is not an end, but a means. The main problem of domestic pharmaceutical companies is that there are too many. Whether it is the experience of the United States, Japan, or Northern Europe, the bigger the pharmaceutical companies, the stronger they are. Reorganization is also an inevitable way. There are currently more than 4,000 pharmaceutical companies in China, which are too many. The generic drugs that make generic drugs are not evenly distributed, and the development of original drugs..." Yang Rui laughed twice, then shook his head, his words were not surprising. He said endlessly: "I think it is enough to keep the number of domestic pharmaceutical companies around 100. In the short term, it is necessary to control the scale of pharmaceutical companies to 1,000."

Historically, the implementation of the GMP system has reduced the number of pharmaceutical companies in China from 4,000 to 2,000. Yang Rui’s attitude is naturally more resolute and radical. After all, the current small pharmaceutical companies with an annual output value of hundreds of millions of yuan , are basically evils produced by local protection, and there is no market competitiveness at all, and even some pharmaceutical companies are now in a state of loss-under the condition that the government's public power provides raw material guarantees, and drug procurement is governmentalized, it can still Incurring losses, let alone the value of such a pharmaceutical company, the products produced are all fake and inferior products, but patients have no right to choose and resist.

The three big brothers couldn't help but fell into deep thought, and Mr. Qiao suddenly regained his spirit. He is in favor of large-scale mergers and reorganizations of domestic companies. Starting from pharmaceutical companies, there are legal incentives. And being able to implement the shutdown and transfer of the entire industry is naturally more in line with his governance philosophy.

Mr. Tang and Mr. Li's governance philosophy is more peaceful, but Yang Rui's statement has shaken their positions.

Indeed, 4,000 pharmaceutical companies are indeed too many.

China's economic policy has always tended to be large and comprehensive, because under the planned economy system, small and beautiful companies almost do not exist, and it means high management costs that are difficult to achieve.

China's railway industry, heavy machinery manufacturing industry, petroleum industry, finance, communications, aerospace and other fields are all dominated by one company or monopolized by several companies. As far as the current situation is concerned, they are all relatively well-operated industries, especially Compared with industries such as coal mines and textiles, management efficiency and profit margins are not a little bit better.

To develop the pharmaceutical industry, 4,000 pharmaceutical companies are definitely not enough. It can even be said that the existence of 4,000 pharmaceutical companies has challenged the survival of the entire pharmaceutical industry. Now there are foreign outsourcing orders, which make many pharmaceutical companies live. It is quite nourishing, but how long can it last by relying on such low-end imports and exports?

Therefore, reducing the size of pharmaceutical companies is almost a must.

Tang Gong and Li Lao asked several questions in succession, and after Yang Rui answered, they gradually fell into deep thought.

Mr. Qiao said in a hot tone: "Yang Rui, shutting down and switching over is a big proposition, you should also talk about it."

Yang Rui hesitated for a moment and said, "This is about management."

"You're just talking about pharmaceutical companies. The pharmaceutical industry is your specialty. Besides, didn't you have suggestions in this regard before?" Qiao Gong sold Yang Rui to the stage without hesitation.

Yang Rui couldn't shirk it, hesitated for a moment, and said: "In my opinion, what pharmaceutical companies need most is capital, followed by technology and equipment, and the demand for manpower is the lowest. Compared with the machinery manufacturing industry, the automation of pharmaceutical companies The level can be raised to a very high level. Therefore, although skilled workers are needed, the quantity requirements are actually reduced. In other words, the most important thing in merging and reorganizing pharmaceutical companies is financial integration, followed by technical improvement and complementarity. Then there is the addition and complementation of equipment, and in the end, it is probably necessary to divert a large number of workers."

Yang Rui did not use words such as elimination or layoffs, because before the concept of "layoff" was proposed, workers had a lifelong occupation, and occasionally state-owned enterprises that were shut down and transferred also had to reassign workers to work.

Still, shunting is a brutal and unavoidable topic.

Mr. Qiao had already thought about it, looked at Tang and Li, and said, "I think what Yang Rui said is very reasonable. If we don't want to do a pilot, we can use the Jingxi Pharmaceutical General Factory, which has violated laws and regulations, as a pilot. ,How about it?"

"The scale of Jingxi Pharmaceutical General Factory is very large." Tang Gong raised his head.

Mr. Qiao just wanted a big one, so he immediately said: "Big ones have great benefits, and they can fully discover problems. Moreover, the handling opinion reported by the Ministry of Health is to shut down and turn them on. This is a ready-made test material."

Mr. Tang didn't speak, but Mr. Li said: "I agree, but we can't simply shut down the matter, even if we deal with it, it must be dealt with meaningfully."

"I agree, we can analyze it now." Qiao Gong regained his energy, and his eyes were shining.

...

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